David Boies And Theodore B. Olson, Bipartisan Gay Marriage Lawyers, Land Book Deal

NEW YORK -- The bipartisan legal team leading the fight for gay marriage has a book deal.

Democrat David Boies and Republican Theodore B. Olson have signed with Viking for "A Just Cause: Law, Love, and the Case for Marriage Equality." Viking told The Associated Press on Wednesday the book is scheduled for mid-2014.

"Our collective journey tells of a crucial and historical civil rights movement that brings us closer to the ideals on which our country was founded," Boies, 71, said in a statement issued by Viking.

Olson, 72, said he and Boies between them have "nearly 100 years in the law."

"We have never handled a more important, dramatic and emotionally compelling challenge," he said in a statement.

Boies and Olson have formed an unlikely partnership to represent the challengers to Proposition 8, approved by California voters in 2008. The ballot initiative overturned a state Supreme Court decision allowing gay marriage. Justices on the U.S. Supreme Court will hear arguments in the California case on March 26.

Boies and Olson were on opposite sides for one of the court's most historic cases, when Boies represented Democratic presidential candidate Al Gore and Olson represented Republican George W. Bush in a dispute over the Florida vote count in 2000. The court ruled 5-4 in Bush's favor.

Viking, an imprint of Penguin Group (USA), promised the Boies-Olson book will be a "dramatic, intimate, and informed account of this historic issue."

Also on HuffPost:

• Connecticut

  Since November 12, 2008

• Iowa

  Since April 3, 2009

• Maine

  In 2012, Maine voted in favor of a ballot amendment to legalize gay marriage.

• Maryland

  The gay marriage bill was signed into law by Gov. Martin O'Malley (D) on March 1, 2012. Opponents later gathered enough signatures to force the issue back onto the ballot in November 2012, but voters rejected the effort against gay marriage.

• Massachusetts

  Since May 17, 2004

• New Hampshire

  Since January 1, 2010

• New York

  Since July 24, 2011

• Vermont

  Since September 1, 2009

• Washington

  On February 13, 2012, Gov. Christine Gregoire (D) signed a law allowing same-sex marriage ceremonies to begin on June 7, 2012. The process was delayed by gay marriage opponents who gathered enough signatures to put the issue up to a state vote in November 2012. They voted to approve it on Election Day.

• Washington D.C.

  Since March 9, 2010

• California

  The state initially began conducting gay marriages on June 16, 2008. On November 5, 2008, however, California voters passed Proposition 8, which amended the state's constitution to declare marriage as only between a man and a woman.

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Source: http://www.huffingtonpost.com/2013/02/27/david-boies-theodore-b-olson-gay-marriage-book-deal-_n_2777732.html

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Baseball fan can sue: Jury will decide risk of watching ball

An injured baseball fan can sue for damages, ruled the Idaho Supreme Court today. The fan lost an eye after being hit in the face with a foul ball at a minor league game.

By Rebecca Boone,?Associated Press / February 26, 2013

The Chicago Cubs play an exhibition spring training baseball game against the Colorado Rockies, Feb. 26 in Phoenix. A fan injured by a foul ball at a Cubs farm team game in Boise can sue, the Idaho Supreme Court ruled today.

Morry Gash / AP

Enlarge

A man who lost an eye after being hit by a foul ball at a?baseball?game can seek damages from a minor league team in Idaho.

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The Idaho Supreme Court decided not to impose the "Baseball?Rule" of liability in the lawsuit brought by Bud Rountree, instead choosing to let a jury decide if watching?baseball?is an inherently dangerous activity done at the spectator's own risk. Rountree was struck by a ball while watching the Boise Hawks, a Chicago Cubs farm team.

Loyola Law Sports Institute Director Daniel Lazaroff said the decision was a rare strikeout for the?Baseball Rule, which has been adopted by courts in Massachusetts, New York, Michigan and elsewhere. But he said the Idaho court made the right call in finding the legislature should decide if stadium owners deserve special legal protections.

The rule has several iterations, but basically holds that stadium owners can't be held liable if?fans?are injured by thrown or batted balls. Frequently, ticket stubs to sporting events will be printed with a disclaimer saying the holder assumes all risks associated with ball-related injuries, as was the case in the Idaho lawsuit.

"The trend in other courts has been contrary to this Idaho case," Lazaroff said.

Lazaroff said similar lawsuits are likely to arise in the wake of Sunday's NASCAR crash at Daytona International Speedway. The crash left at least 33 spectators injured when a car flew into a fence, hurling a tire and debris into the stands.

"There are lawyers who have said the ticket-stub disclaimer will be sufficient but I have my doubts. It's not like you're signing on the dotted line that you've read the ticket," Lazaroff said.

Rountree was injured while attending a Boise Hawks game with his wife and grandkids on Aug. 13, 2008. Rountree left his seat in the mesh-netting protected section of the stadium and was talking to someone in an area not protected by netting when he heard the crowd begin to roar. That's when Rountree turned toward the field and was struck in the face with a foul ball, according to the ruling, and the resulting injury caused him to lose an eye.

Rountree sued the Boise Hawks, the stadium owner and others, alleging their negligence was to blame for his injury.

John Nockleby, a professor and director of the civil law program at Loyola Law School, said thrown or batted ball injuries are freak accidents but not necessarily uncommon issues in the courts.

"Do you want to impose the costs of these kinds of events on a member of the crowd, or do you want to say that the?baseball?stadium owner should take charge of the cost by putting up netting or insuring against damages?" Nockleby said. "One side says, 'We want to keep people close to the action ... the other side says, 'It's a randomly hit ball and a lot of the time people don't know how serious the risk of injury is.'"

Lawmakers in some states, including California and New Jersey, created laws specifically to shield stadium owners from being held liable for injuries. But Idaho lawmakers have never created such a rule, and the state's court rulings on other kinds of liability cases have found that companies can't get blanket protection from liability simply by printing a disclaimer.

The unanimous Idaho Supreme Court last week said justices had the power to adopt the?Baseball?Rule, but they declined to do so.

Baseball?spectator injuries are rare in Idaho, Justice Jim Jones wrote on behalf of the full court, and there doesn't seem to be a compelling public policy reason for judges to step in.

Rountree's attorney, W. Breck Seiniger of Boise, said he was pleased by the ruling, especially given that stadiums today are multi-use facilities with concession stands and other facilities that encourage spectators to turn their backs on the fields.

Joshua Evett, the attorney for the Boise Hawks and other defendants, did not immediately return a phone call requesting comment.

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/AdIvfQUXzgI/Baseball-fan-can-sue-Jury-will-decide-risk-of-watching-ball

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'Stormin' Norman' to be laid to rest at West Point

One of the most celebrated generals of the 20th Century, Norman Schwarzkopf is being lauded by presidents and military leaders as a true patriot. NBC's Andrea Mitchell reports.

By Matthew DeLuca, Staff Writer, NBC News

Norman Schwarzkopf, the general who commanded the 30-country coalition that drove Saddam Hussein?s forces out of Kuwait, will be laid to rest on Thursday at the U.S. Military Academy at West Point. A 1956 graduate of the military academy, ?Stormin? Norman? will be buried after a memorial service at the West Point chapel.

The Desert Storm commander with a tough-as-tacks reputation died on Dec. 27 in Tampa, Fla., of complications from pneumonia. He was 78.

Schwarzkopf served two tours in Vietnam, staying on after a conflict that left many former brothers-in-arms disillusioned with the military.

He was appointed commander in chief of the U.S. Central Command at MacDill Air Force Base in Tampa in 1988. In 1990, he took command of the U.S.-led forces that drove back Hussein?s forces in Operation Desert Storm.

It was the first war televised in real time, and Schwarzkopf, a bulldog clad in desert camouflage, used his TV appearances to send a message to his adversary.

?With those cameras grinding away, I knew I wasn?t talking just to friendly audiences, but that Saddam and his bully boys were watching me on CNN in their headquarters,? Schwarzkopf wrote in his 1992 autobiography.

For the most part, Schwarzkopf receded from public life after Desert Storm, apart from a brief term as a military analyst for NBC. He lived out his retirement in Tampa, emerging to campaign for the re-election of President George W. Bush in 2004.

Schwarzkopf ?stood tall for the country and Army he loved,? President Obama said in a statement on the general?s passing in December.

The general will be buried near his father in the West Point cemetery. Col. H. Norman Schwarzkopf was a 1917 graduate of the military academy who went on to help found the New Jersey State Police.

?I just would be very happy if the history books said that I was a soldier who served his country with honor and loved his troops and loved his family,? Schwarzkopf once said. ?That?s enough for me.?

The Associated Press contributed to this report.

Related:

Source: http://usnews.nbcnews.com/_news/2013/02/28/17130970-stormin-norman-desert-storm-commander-to-be-laid-to-rest-at-west-point?lite

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SES New York Keynote Speaker Says Internet is TV's Best Friend ...

The Internet didn?t kill TV! According to Mike Proulx, the Internet has become TV?s best friend. Proulx will be the opening keynote speaker at SES New York 2013. The leading event for experienced marketing and advertising professionals will take place March 25-28, 2013, at the New York Marriott Marquis.

Proulx is a Senior Vice President and the Director of Social Media at Hill Holliday, a renowned advertising agency based in Boston, where he leads a team with a focus on cross-channel integration, emerging and social media. He has spent the last 17 years working at various interactive, high-tech, and new media companies on the agency-side, client-side, and as an entrepreneur. He has spoken at dozens of events and has been widely featured in the press including The New York Times, Fast Company, TV Guide, Forbes, BusinessWeek, Mashable, BuzzFeed, and NPR.

Proulx conceived, produced, directed, and co-host the TVnext summit, which took place in early 2011 and 2012. He is the co-author of Social TV, a best-selling book from Wiley publishing that launched in February of 2012. He is also the host of the social TV web series, ?The Pulse on Lost Remote?. He holds a Master?s degree in Computer Information Systems from Bentley University and in 2012 was named the Ad Club?s Media All Star.

His opening keynote is titled, ?Social TV: How Marketers Can Reach and Engage Audiences by Connecting Television to the Web, Social Media, and Mobile.?

Search Engine Watch (SEW) asked Mike Proulx (MP) five questions about his upcoming keynote. Here are his answers:

SEW: How does the convergence of television with the web, social media, and mobile change our behaviors and shake up our long standing beliefs about TV?

MP: There are those who believe that television is a traditional medium with an impending death. The web, social media, and mobile have evolved TV into a multi-screen experience that transcends devices. Not only are we watching more television than ever before, we?re interacting with programming on the ?second screen? in ways that enrich storylines and bring us together to virtually co-view. The modern era of television is a new media that?s more social, more connected, and more portable?and because of this TV is more alive than it?s ever been.

SEW: How has social media created a new and powerful "backchannel" and why does this fuel the renaissance of live broadcasts?

MP: There are a ton of posts happening in social media about any given TV show as it airs. Since Twitter is open and public, it acts as television?s backchannel filled with real-time commentary and conversation ? And it?s not just about TV series but also TV commercials giving producers and marketers instant feedback about their content. Live television events are seeing some of the highest ratings in years and social media brings a level of community and connection to TV watching the likes of which the medium has never before experienced.

SEW: Can you give us some examples of how mobile devices allow us to watch and interact with television whenever and wherever we want?

MP: Tablets, smartphones, and laptops enable television?s portability but it?s apps like HBO Go, ABC Player, Xfinity Remote, and CNN that deliver ?TV? content via those devices. And in the 4G world of mobile, we can watch TV in places once inconceivable. My favorite spot? Laying out on the roof deck on a warm summer night with my iPad in hand streaming HBO?s The Newsroom.

SEW: Why would ?connected TVs? blend web and television content into a unified big screen experience that will bring us back into our living rooms?

MP: Apple TV, Roku, Boxee TV, Google TV, Samsung Smart TVs, etc. stream online video (that was once relegated to our computer screens) onto the ?big screen? of our living rooms. HD YouTube clips suddenly come to life in ways that are far more impactful and dynamic than tiny smartphone screens further blurring the lines of what?s ?TV.? While the notion of TV everywhere lets us watch TV at will regardless of our physical location, the increasingly seamless ability to channel streaming video through the TV set makes the living room that much more compelling.

SEW: With the television landscape changing, why should brands approach the medium once labeled ?traditional? as new media?

MP: TV has become mashed up with the Web, social media, and mobile. Television networks, providers, brands, and agencies must continue to unshackle themselves from dated business and advertising models and rediscover television as a new medium. This means planning television and digital together to tell stories across devices and engage viewers with TV experiences not just TV shows. The speed, scale, and degree of change that has and is happening create enormous opportunity for those brands who have the courage to innovate.

SES New York 2013 offers a variety of conference passes and on-site training. If you register by Thursday, March 7, 2013, you can save up to $600 on Platinum or All Access passes.

For more information, click on Rates and Registration Details. Group discounts for 4 or more pass holders from the same company are also available by contacting [email?protected] and are the best value for the lowest price possible.

I should disclose that SES New York is a client of my agency. But, trust me, TV is not dead yet.

---

Become an Expert Digital Marketer at SES New York
March 25-28, 2013: With dozens of sessions on Search, Social, Local and Mobile, you'll leave SES with everything and everyone you need to know. Hurry, early bird rates expire February 21. Register today!

Source: http://searchenginewatch.com/article/2250850/SES-New-York-Keynote-Speaker-Says-Internet-is-TVs-Best-Friend

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NVIDIA back with videos showing off gaming graphics at MWC 2013 ...

NVIDIA is back on their blog today about their new Tegra 4 chips, this time with information about games primed for Tegra powered devices. Games are a great way to show off the computing power of a new chip as NVIDIA demonstrates in a couple videos from Zombie Driver and RU Golf. With more computing power, graphics can display better textures and more polygons, making for smoother results. The new Tegra 4 chip will also let game developers take advantage of features like dynamic lighting to create accurate shadows.

Along with the enhancements, NVIDIA also released some information about five games that will be released soon specifically targeted at Tegra-powered devices, including:

• Burn Zombie Burn from Tick Tock Games, your typical zombie-fighting console game;
• Carie: Blood Mansion from Neowiz will include an exclusive map for Tegra device users in this action adventure game. Tegra device owners will also be able to enjoy high-res textures, enhanced physics simulations and optimized fire and smoke effects;
• RPG CODEX: The Warrior from Devclan and Playbean is an action/fighting title in which the player is battling a variety of monsters. The title will take advantage of real-time dynamic shadows and HDR lighting;
• Dead on Arrival 2 from N3V Games, another game pitting the player against zombies, this one taking advantage of high-res models;
• RU Golf from Nutgee takes the Tegra platform to a different genre where the cartoon/anime graphics take advantage of dynamic specular lighting, shadows, bloom and lens flare effects.

You can check out the comparisons between the current capabilities of Tegra devices compared to the new Tegra 4 chips in the videos below. Be sure to check back for more MWC 2013 coverage.

source: NVIDIA

? See more articles by Jeff Causey

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Recluse's gold fortune to be auctioned for taxes

CARSON CITY, Nev. (AP) ? Even though he lived in the same quiet neighborhood for decades, no one seemed to know Walter Samaszko Jr. He was so unknown that weeks passed before authorities discovered he had died in his modest Carson City home.

When cleanup crews arrived, they made another startling discovery: The 69-year-old man who had lived so simply had a vast collection of thousands of gold coins worth millions of dollars stashed in old ammunition boxes in his garage.

About half of the collection's value will be auctioned off Tuesday in a Carson City courtroom to satisfy some $800,000 in government estate taxes and fees.

The profits from any sales beyond that amount will go to a substitute teacher in San Rafael, Calif., who is Samaszko's first cousin and sole heir. It took an exhaustive search to locate Arlene Magdanz.

The auction will include only the bullion coin collection, not the collector's edition coins, said Alan Glover, Carson City's clerk recorder who will oversee the auction.

"They're buying and bidding on an ounce of gold, pure gold by the weight," Glover said.

The bidders are all professional coin collectors who regularly make purchases ranging from $3 million to $10 million, he added.

Coins have been grouped into 11 sets based on type, and the sets have been weighed by the ounce. The collections range from 24.1 troy ounces to 602 troy ounces.

In total, about 135 pounds of gold is to be sold at auction, which Glover said is expected to net about $3 million. Another auction for the larger half of the collection is likely later, he said.

Officials discovered the trove neatly wrapped and stored mostly in ammunition boxes stacked on top of each other. There were more than 2,900 Austrian coins, many from 1915; more than 5,000 from Mexico; at least 500 from Britain; 300 U.S. gold pieces, some dating to 1880; and more than 100 U.S. gold pieces as old as the 1890s.

Among the coins were meticulous records of the purchases dating back to at least 1964, when gold averaged about $35 per ounce. The precious metal currently sells for nearly $1,600 an ounce.

Authorities believe that his mother, who lived with Samaszko until her death in 1992, purchased most of the coins.

Despite the millions of dollars in his garage, Samaszko didn't appear to lead a luxurious life. Records show he only withdrew about $500 a month to pay modest bills. He died with $1,200 in a checking account and just a bit more than $165,000 in a money market and mutual fund account.

Since learning of her inheritance, Magdanz has shunned publicity and not made any comments about the fortune.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2013-02-26-US-Recluse's-Gold-Fortune/id-850d734620554850a8abec78f3e7116c

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Zynga Joins Gamble on Online Gambling | Mobile Marketing Watch

February 26, 2013 -- By Jared

Last week, MMW reported on the surge among Silicon Valley investors and other digital powerhouses looking to bet on the next billion-dollar industry: online and mobile casino games.

On Tuesday, another giant name in the social gaming space stood up to plant its flag in this burgeoning real-money gaming arena.

Zynga CEO Mark Pincus says his company will make gambling games more social. First market? The U.K.

?It makes it more exciting than when you?re by yourself in an anonymous poker room,? Pincus said today, confirming his company?s aims for later this year.

According to CNET, Zynga will introduce real-money gaming to a mass market ?in the same way it introduced social gaming to the general public.?

?We?re not the company to win the hardcore real-money gamers,? Pincus reveals. ?But we think we are for the mass market audience.?

With states like Nevada and New Jersey rapidly moving to legalize online gambling, there?s no telling how soon before companies like Zynga and others make the U.S. their central focus in online gambling.

But that day is rapidly approaching.

Source: http://www.mobilemarketingwatch.com/zynga-joins-gamble-on-online-gambling-29732/

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The Yeshiva World Brooklyn: Drunk Driver Who Killed Moshe ...

Brooklyn: Drunk Driver Who Killed Moshe Berkowitz Z?L Gets Convicted

(Monday, February 25th, 2013)

Kings County District Attorney Charles J. Hynes today announced the conviction of Anel Kolenovic, 25, on charges of Manslaughter in the Second Degree, Operating a Motor Vehicle While Impaired, and Assault in the Second Degree. He was charged with killing the driver of a car he struck while speeding down Ocean Avenue drunk in November 2010. He faces a maximum of five to 15 years in prison when he is sentenced on March 18 before Brooklyn Supreme Court Justice John Ingram.

On November 29, 2010, Kolenovic was speeding down Ocean Avenue and ran a red light at Avenue N, in Midwood, where he hit Moshe Berkowitz?s car, killing Berkowitz. Two passengers in Kolenovic?s car were injured. Kolenovic was intoxicated at the time of the incident.

The case was prosecuted by Gayle Dampf, Chief of the Vehicular Crimes Bureau and Assistant District Attorney Seth Zuckerman from the Trial Bureau Orange Zone.

(YWN Desk ? NYC)

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Source: http://www.theyeshivaworld.com/?p=158380

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How Bad Did Analytics Bugs Fool Facebook Pages? Reach Looked Down 14% When It Wasn?t

Months of mysterious Insights bugs duped Facebook Page owners. The median Page's analytics showed it reached 14.39 percent fewer people than it actually did, according to early data and graphs from EdgeRank Checker, a Facebook analytics startup that gave us the first look. The bugs may have caused people to mistakenly undervalue their Pages, change strategies or buy ads to make up for "lost" reach

Source: http://feedproxy.google.com/~r/Techcrunch/~3/Olgc5UTBlXc/

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'Jimmy Kimmel Live!' Oscars Show: 'Movie The Movie 2V' And More

Bruno Mars, Matt Damon, Bradley Cooper, Jessica Chastain and more stars join in on the parody sequel.
By Drew Taylor

Jimmy Kimmel and Jessica Chastain in "Movie: The Movie: 2V "
Photo: ABC

Source: http://www.mtv.com/news/articles/1702533/jimmy-kimmel-oscars-special-2013.jhtml

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Pediatricians oppose school suspension, expulsion

NEW YORK (Reuters Health) - A group representing pediatricians says disciplining students with out-of-school suspension or expulsion is counterproductive to school goals and should only be used on case by case basis.

The policy statement from the American Academy of Pediatrics (AAP) recommends that pediatricians familiarize themselves with the policies of their local school districts, and advocate for prevention and alternative strategies.

"The adverse effect of out-of-school suspension and expulsion on the student can be profound," the experts write in the journal Pediatrics on Monday.

"Data suggest that students who are involved in the juvenile justice system are likely to have been suspended or expelled. Further, students who experience out-of-school suspension and expulsion are as much as 10 times more likely to ultimately drop out of high school than are those who do not," they add.

Kathy Cowan, director of communications for the National Association of School Psychologists in Bethesda, Maryland, said their organization largely supports the AAP's statements.

"Sometimes (out-of-school suspension and expulsion) are absolutely necessary, but they're not effective at improving behavior in general," Cowan told Reuters Health.

The AAP says students who are punished with out-of-school suspension and expulsion may be left without supervision during the day and engage in more inappropriate behavior.

The experts also say out-of-school suspension and expulsion does not deal with possible underlying issues, such as drug abuse, racial tension, violence and bullying.

In addition to the costs incurred by the school district from disciplinary hearings and providing services for the child, the pediatricians say there is also a cost to society.

"A high-school dropout will earn $400,000 less over a lifetime than a high school graduate. The dropout will pay $60,000 less in taxes," they write.

To prevent out-of-school suspensions and expulsions, the pediatricians suggest developing early interventions for preschool children, early identification of children who may have problems in school and clear codes of conduct.

Specifically, they recommend a Positive Behavior Intervention and Support program as a preventive, alternative, tool that teaches proper behavior on a school-wide level and that addresses problems with groups and individual students as well.

The AAP also called on Pediatricians to screen for and recognize behavioral problems in early childhood, to be in communication with the school's nurse or counselor, to be involved with special accommodations for certain students and to be appropriately compensated for their involvement.

Cowan said the AAP should be applauded for their efforts.

"Pediatricians are such an important voice on these issues, because parents trust the pediatricians and they're the ones seeing kids," she said.

Dr. Jeffrey Lamont, the policy statement's lead author, did not respond to requests for comment.

SOURCE: http://bit.ly/HjQ8dI Pediatrics, online February 25, 2013.

Source: http://news.yahoo.com/pediatricians-oppose-school-suspension-expulsion-052138323.html

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General mechanism that accelerates tumor development discovered

Feb. 24, 2013 ? Cancer is characterized by uncontrolled cell division and growth. In order to identify new therapeutic targets through which to tackle the disease, scientists seek to clarify the mechanisms that control the expression of genes that favor the development of tumors, in processes such as uncontrolled cell division. Nature has just published a paper by the lab headed by Ra?l M?ndez, ICREA professor at the Institute for Research in Biomedicine (IRB Barcelona). The study describes a mechanism controlled by the CPEB1 protein that affects more than 200 genes related to cell proliferation and tumor progression. The mechanism, which was discovered using Hodgkin lymphoma cells, has been proposed as a general regulatory system that enhances the spread of cancer.

The researchers describe that CPEB1 shortens a highly specific region of RNAs (RNAs are the molecules that carry gene information for protein synthesis). This region holds most of the signals that determine whether an RNA molecule is made into a protein or not. "CPEB1 "takes off the brakes" for hundreds of RNAs that stimulate cell desdifferentiation and proliferation, allowing them to be made into proteins; however, in addition to removing the brakes in the nucleus, this protein accompanies RNA to the cytoplasm, where it speeds up the production of these proteins," explains the senior author of the paper Ra?l M?ndez, head of the "Translational control of cell cycle and differentiation" group at IRB Barcelona.

Ra?l M?ndez is an expert on the CPBE protein family, a type of RNA-binding protein that has a positive and crucial role in early embryo development. "CPEB proteins are necessary during development and also during tissue regeneration via stem cells in adults, but if the programme governed by CPEBs is continually switched on, cells divide when they are not supposed to and form a tumor," explains M?ndez. The CPEB family comprises four proteins, which compensate each other's normal function but which have specific activities in diseased states. "This finding is positive from a therapeutic viewpoint because it means that if you remove CPEB1 from healthy cells, its function can be taken over by any other CPEB protein. In contrast, in tumors only CPEB1 has the capacity to shorten these regions, thus affecting only tumor cells," states Italian researcher Felice Alessio Bava, first author of the paper, and post-doctoral fellow with M?ndez's group who, this year, has obtained his doctorate degree through the "la Caixa" International Fellowship Programme. This study provides further evidence of the potential of CPEB proteins as therapeutic targets. In 2011, in a study published in Nature Medicine, M?ndez identified that CPEB4 "switches on" hundreds of genes linked to tumor growth. This new study explains that the overexpression of CPEB4 in tumors is because CPEB1 has also "released its brakes." "The fact that these proteins control each other is also advantageous from a therapeutic point of view," asserts M?ndez, "because partial inhibition, by a drug, would be amplified, thus allowing tumor cell reprogramming. The amplification should make it easier to find a viable compound."

The lab has developed a system to screen therapeutic molecules for a drug that can inhibit the action of CPEB in tumors while having few secondary effects on healthy cells. "There is no drug currently available that influences the regulation of gene expression at this level. Our findings open up a pioneering therapeutic window. We are optimistic about the potential of CPEB proteins as targets," says M?ndez.

The action of CPEB proteins should be considered in the design of other therapeutic strategies

The study published in Nature includes a meticulous genomic analysis of RNA molecules that are processed in different ways depending on whether CPBE1 is present. The study provides a list of between 200 and 300 of such genes, that is to say, those that would have the region holding regulatory signals removed. This is precisely the region where microRNAs -- small molecules regulating the translation of this RNA to protein -- bind. "Many antitumor therapies attempt to interfere with microRNA binding, but we have now revealed that CPEB proteins remove these regions beforehand. The pharmaceutical companies that are developing such compounds will be able to predict whether their targets are suitable approaches or not," explains the scientist.

The study has involved the collaboration of the group led by Juan Valc?rcel at the Center for Genomic Regulation (CRG), an expert in RNA nuclear processing, and that of Roderic Guig?, an expert in biostatistics and also at CRG. This study received funding from the Consolider RNAreg consortium of the Spanish Ministry of Economy and Competition and the Generalitat de Catalunya (Government of Catalonia).

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Story Source:

The above story is reprinted from materials provided by Institute for Research in Biomedicine (IRB Barcelona).

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

---

Journal Reference:

1. Felice-Alessio Bava, Carolina Eliscovich, Pedro G. Ferreira, Belen Mi?ana, Claudia Ben-Dov, Roderic Guig?, Juan Valc?rcel, Ra?l M?ndez. CPEB1 coordinates alternative 3?-UTR formation with translational regulation. Nature, 2013; DOI: 10.1038/nature11901

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/6AD_azErazs/130224142827.htm

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[iPhone] Activation with SAM

Forum Jump

Source: http://forums.macrumors.com/showthread.php?t=1547428&goto=newpost

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The Best Late Night Clips Of The Week: Obama?s Golf Trip, McCain?s Hypocrisy, Biden?s Shotgun And More

Sunday, February 24th, 2013 at 12:08am Mediaite

"); nggCapArray.push("President Obama's golf vacation in Florida has been off-limits to the press, but he did take a few minutes out of his busy schedule to chat with David Letterman on the phone.rnrn

"); nggCapArray.push("Jon Stewart tonight took on Republican senators Lindsay Graham and John McCain for their hyped-up outrage over Benghazi that led both to support holding up Chuck Hagel's nomination for Defense Secretary in order to get answers. Stewart tore into McCain specifically for having the hubris to demand answers for Benghazi when he did no such thing regarding the Iraq war and his motivations for blocking Hagel were not exactly free of personal bias.rnrn "); nggCapArray.push("Vice President Joe Biden made headlines Tuesday when he advocated that people "buy a shotgun," instead a more powerful semi-automatic weapon, during a Facebook Town Hall event. But according to recently-announced 2013 White House Correspondents Dinner headliner Conan O'Brien, that wasn't Biden's only controversial statement. rnrnrn"); nggCapArray.push("Daniel Day-Lewis is pretty much considered a lock for this year's Best Actor Oscar, but Hugh Jackman makes a last-minute play for votes by bringing his musical skills to the character of Abraham Lincoln on the Late Show. rnrn"); nggCapArray.push("Rob Delaney is quite possibly the funniest person on Twitter, so Jimmy Kimmel decided to find out what it's like when old people read his tweets. rnrn"); nggCapArray.push("On Monday we reported that after 148 years the state of Mississippi has finally gotten around to ratifying the 13th amendment banning slavery. In order to properly cover this story, The Daily Show was forced to travel back in time to the year 1865 for a special edition of "19th Century News."rnrn "); nggCapArray.push("After five extra days stranded at sea without access to running water, electricity and many other amenities cruise ship passengers typically take for granted, Carnvial's Triumph finally limped back to shore last week. Now, Triumph the Insult Comic Dog wants to make sure no one associates him with the world's worst ship. rnrn"); nggCapArray.push("If you haven't gotten a chance to watch this year's Oscar nominees for Best Picture, The Roots' Black Thought has you covered with this rap summing up the 9 films. rnrn"); nggCapArray.push("The Daily Show's Jessica Williams traveled to Texas this week to see how the people of that state of coping with President Obama's second term. While she may not have found a representative sample of Texans, she did come across a handful of citizens fighting against the "tyranny" of the federal government and holding out for the day Texas can secede from the Union once and for all. rnrn "); nggCapArray.push("Jimmy Kimmel wanted to know what black people think about this year's mostly-white Oscar nominees, so he hit his local barbershop to get some opinions. rnrn"); nggCapArray.push("Dating back to their epic Ben & Jerry's ice cream war, the saga of best friends forever (for six months) Jimmy Fallon and Stephen Colbert continued this week with a "friendly" rendition of "Ivory and Ivory."rnrn"); nggCapArray.push("Totally Biased's W. Kamau Bell was sick of seeing people complaining on Twitter that there's no "White History Month," so he decided to explain to America there could be no Black History Month without white people.rnrn"); nggCapArray.push("First Lady Michelle Obama is making her second appearance on Late Night with Jimmy Fallon Friday night, and as the show wrote on Twitter, they just "couldn't wait" until tonight to show America this epic segment.rnrn"); nggHeightArray.push('247'); nggHeightArray.push('246'); nggHeightArray.push('246'); nggHeightArray.push('245'); nggHeightArray.push('246'); nggHeightArray.push('246'); nggHeightArray.push('246'); nggHeightArray.push('246'); nggHeightArray.push('246'); nggHeightArray.push('246'); nggHeightArray.push('244'); nggHeightArray.push('246'); nggHeightArray.push('246'); nggHeightArray.push('245'); $ ('#am-ngg-ss-cont').append(" n n n n

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>> Follow Matt Wilstein (@TheMattWilstein) on Twitter

Source: Mediaite

Source: http://www.politifreak.com/the-best-late-night-clips-of-the-week-obamas-golf-trip-mccains-hypocrisy-bidens-shotgun-and-more/

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Samsung Galaxy S III Android 4.2.1 Jelly Bean test firmware leaks

Samsung has been going out of its way to keep its Galaxy S III consumer base satisfied. They delivered the original Jelly Bean update in due time and as it seems, they are already working on an Android 4.2.1 Jelly Bean update for its third generation Galaxy S smartphone.

The latest I9300XXUFMB3 Android 4.2.1 Jelly Bean test firmware has been leaked and the official roll out of the final version might just be around the corner.

The Android 4.2.1 Jelly Bean for Galaxy S III is still under the testing phase and the latest update is said to come out with an improved ripple effect on lock-screen, new Android 4.2 lock-screen with widgets, day dreaming, new additions in notification center and voice command, which allows you to control various functions of the Galaxy S III.

Images from Android 4.2.1 test firmware for Galaxy S III

Samsung Galaxy S III Android 4.2.1 Jelly Bean test firmware is available in the source link below and the process of flashing your smartphone involves some risk and would void your warranty, so proceed with the instructions only if you are sure about what you are doing.

Source

Source: http://blog.gsmarena.com/samsung-galaxy-s-iii-android-4-2-1-jelly-bean-test-firmware-leaked/

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Highlands, N.J., Proposes Raising the Borough to Escape Hurricanes

[unable to retrieve full-text content]Officials say that flood-prone Highlands, along the Jersey Shore, could be raised, to prevent damage from future storms.

Source: http://www.nytimes.com/2013/02/23/nyregion/highlands-nj-proposes-raising-the-borough-to-escape-hurricanes.html?partner=rss&emc=rss

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Video: What Happened to the Beauty Queen, Part 6

Dateline NBC

'Dateline NBC,' the signature broadcast for NBC News in primetime, premiered in 1992. Since then, it has been pioneering a new approach to primetime news programming. The multi-night franchise, supplemented by frequent specials, allows NBC to consistently and comprehensively present the highest-quality reporting, investigative features, breaking news coverage and newsmaker profiles.

Source: http://www.nbcnews.com/id/3032600/vp/50914630#50914630

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Samsung Galaxy SIII Discussion and Owners Thread

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? Reply # 587884 posted on 28-Feb-2012 15:51
http://www.stuff.co.nz/technology/gadgets/6493731/Samsung-Galaxy-SIII-specifications-leak I really hope it's not a 4.8" Screen. Please no! If I wanted a big screen TV with me, I would carry a projector! It's a phone Jim! ?

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? Reply # 587887 posted on 28-Feb-2012 15:53
networkn: http://www.stuff.co.nz/technology/gadgets/6493731/Samsung-Galaxy-SIII-specifications-leak The specs have gone down hill if you read the crap they have written

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? Reply # 587891 posted on 28-Feb-2012 16:00
networkn: Downhill? Looks like what I have been seeing all along except the screen has gone from 4.3 to 4.5 to 4.65 to 4.8! 14.4Mbps DL when the SGII supports 21Mbps DL

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? Reply # 587895 posted on 28-Feb-2012 16:06	?
Rumours don't seem very well founded Current Devices: Samsung Galaxy S3 Old Devices: SGS I9000, HTC Sensation, SGSII I9100, Asus Transformer? Associate Editor-in-Chief for AndroidNZ.net TelecomTech?is a sponsored blog reviewing the latest in communications technology. All comments are my own opinion, and not that of my employer unless explicitly stated.

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? Reply # 587911 posted on 28-Feb-2012 16:31

So lets analyze the rumours... from this source: http://www.bgr.com/2012/02/27/samsung-galaxy-s-iii-full-specs-1-5ghz-quad-core-1080p-display-ceramic-case/ 1.5GHz quad-core Samsung Exynos processor Definitely likely 4.8-inch ?full HD? 1080p resolution with 16:9 aspect ratio display Screen size is likely to be similar but 1080p? Heck no A 2-megapixel front-facing camera and an 8-megapixel rear camera Would have expected a higher megapixel sensor here Ceramic case Anything is possible 4G LTE American markets, plus LTE growth in Europe, obvious enough Android 4.0 Well duh, if it was Gingerbread it would be DOA

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? Reply # 588226 posted on 29-Feb-2012 10:54

networkn: Anything I have seen that is ceramic is quite fragile, and if dropped, shatters, including a ceramic knife I owned. Ceramic case doesn't really appeal. more likely a different form of ceramic, such as ceramic they use in turbochargers, bearings, brake discs(carbon ceramic), or bullet proof vests if they made it out of the same stuff as a ceramic knife, there would be chips all over my phone by now!? I have moved across the ditch. ?Now residing in Melbourne as a VOIP/Video Technical Trainer/Engineer.?

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? Reply # 588234 posted on 29-Feb-2012 11:04

networkn: What phone do you have that is ceramic? Cheers Oh, no phone, just a ceramic knife set like yours. ?Was just saying that if my phone was porcelain, I would've chipped/smashed it a long time ago. In terms of ceramics though, they could use a variety of materials. ?Titanium carbide, would be my pick. ?Strong, light, and looks very good! ?It'd be virtual drop/smash proof, if it was incorporated into the lip surrounding the screen. EDIT: Just realised Gorilla glass is basically a glass, and ceramic based material. ?They aren't trying to say that Gorilla glass will be front, and back are they? ?if so, I won't be getting it? I have moved across the ditch. ?Now residing in Melbourne as a VOIP/Video Technical Trainer/Engineer.?

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Source: http://feeds.geekzone.co.nz/~r/GeekzoneForumsLatestPosts/~3/GtISHSpyoLY/forums.asp

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